Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is is a primary mediator of the effects of growth hormone (GH). Growth hormone stimulates the liver to produce IGF-1. IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis.
Alternate Names - IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
IGF-1 Homology Across Species
Acanthisitta chloris (rifleman) IGF-1 – 100%
Alligator mississippiensis (American alligator) IGF-1 – 100%
Alligator sinensis (Chinese alligator) IGF-1 – 100%
Amazona aestiva (blue-fronted amazon) IGF-1 – 100%
Anas platyrhynchos (mallard) IGF-1 – 100%
Anser anser (domestic goose) IGF-1 – 100%
Apaloderma vittatum (bar-tailed trogon) IGF-1 – 100%
Aptenodytes forsteri (emperor penguin) IGF-1 – 100%
Balearica regulorum gibbericeps (East African grey crowned-crane) IGF-1 – 100%
Cariama cristata (red-legged seriema) IGF-1 – 100%
Chelydra serpentina (common snapping turtle) IGF-1 – 100%
Chrysemys picta bellii (western painted turtle) IGF-1 – 100%
Colius striatus (speckled mousebird) IGF-1 – 100%
Coturnix japonica (Japanese quail) IGF-1 – 100%
Crocodylus porosus (Australian saltwater crocodile) IGF-1 – 100%
Ficedula albicollis (collared flycatcher) IGF-1 – 100%
Gallus gallus (chicken) IGF-1 – 100%
Gavialis gangeticus (Gharial) IGF-1 – 100%
Geospiza fortis (medium ground-finch) IGF-1 – 100%
Manacus vitellinus (golden-collared manakin) IGF-1 – 100%
Meleagris gallopavo (turkey) IGF-1 – 100%
Melopsittacus undulatus (budgerigar) IGF-1 – 100%
Numida meleagris (helmeted guineafowl) IGF-1 – 100%
Pelecanus crispus (Dalmatian pelican) IGF-1 – 100%
Serinus canaria (common canary) IGF-1 – 100%
Taeniopygia guttata (zebra finch) IGF-1 – 100%
Tauraco erythrolophus (red-crested turaco) IGF-1 – 100%
Tyto alba (barn owl) IGF-1 – 100%
Cairina moschata (Muscovy duck) IGF-1 – 99%
Chelonia mydas (green sea turtle) IGF-1 – 99%
Pelodiscus sinensis (Chinese soft-shelled turtle) IGF-1 – 99%
Phalacrocorax carbo (great cormorant) IGF-1 – 99%
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